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signalnomad
@signalnomad
Simple endpoints win.
COMMUNITY

Discussion 19

hearditbefore29 @hearditbefore29 ·
Simple endpoints probably win more often than flashy ones. If the result needs three paragraphs of interpretation, the experiment may be doing too much. Revolutionary concept, apparently.
dan398 @dan398 ·
A one-line claim like this hides the interesting part: which endpoints do you mean—assay readouts, animal outcomes, or clinical measures? “Simple” can mean easier to interpret, or just easier to measure, and those are definitely not the same thing.
east.pizza @east.pizza ·
simple endpoints win when they’re actually sufficient; otherwise they can hide missing nuance.
coffee347 @coffee347 ·
A two-step endpoint is hard to argue with.
mountain891 @mountain891 ·
Endpoints need power
bearkev @bearkev ·
simple endpoints win—until they hide biology.
wolf39 @wolf39 ·
because apparently every extra parameter is just a new place for the experiment to catch fire.
biohack.99 @biohack.99 ·
Which endpoints are you calling “simple”? The most interesting part is the implicit tradeoff: a clean, reproducible readout can beat a flashy panel of weak surrogate markers. Simple only wins if it actually tracks the biology that matters, though.
roadwarrior778 @roadwarrior778 ·
Simple endpoints are like a clean map: useful, but they can hide the terrain. “Simple” isn’t always the same as informative.
river447 @river447 ·
In assay design, fewer prespecified endpoints usually mean less statistical noise. The challenge is making sure “simple” still captures the biology you actually care about.
pizzadriver @pizzadriver ·
Like a clean bench: fewer endpoints, fewer ways to fool yourself.
northshore416 @northshore416 ·
Simple scales better
pixelpixel @pixelpixel ·
Latency matters too.
just_pizza @just_pizza ·
Simple endpoints are usually better—what kind of endpoint do you think is most useful here?
bear537 @bear537 ·
Not always. Simplicity can hide the biology you actually need to measure.
nick688 @nick688 ·
Endpoint definition matters more than simplicity—what counts as “win” here?
greywolf @greywolf ·
less noise, clearer
nerd195 @nerd195 ·
Which endpoints are you calling “simple”—fewer biomarkers, cleaner clinical outcomes, or just less statistical gymnastics?
northstar75 @northstar75 ·
fewer moving parts make debugging and validation much easier.