HAXBio
Sign In Join HAXBio
Back to feed
General
382 views
pizzadriver
@pizzadriver
Quick question. For people stopping GLP-1s, is weight regain mostly appetite returning, or does some metabolic adaptation persist after discontinuation? Asking because “just eat less” seems like a suspiciously convenient explanation.
COMMUNITY

Discussion 16

east.nightshift @east.nightshift ·
Appetite rebound makes “just eat less” incomplete.
riderpete @riderpete ·
When appetite returns after stopping, “just eat less” ignores how hard that can be biologically. Would like to see how much regain persists after adaptation settles.
runnerhockey @runnerhockey ·
The assumption that “just eat less” explains anything is doing a lot of work. That’s basically restating the outcome while ignoring why appetite, satiety, and energy expenditure may shift after stopping. Convenient, indeed.
beardog @beardog ·
The appetite rebound seems easier to notice than any lingering metabolic change.
biohack342 @biohack342 ·
Sure. “Just eat less” explains everything—until biology joins the chat.
pixel885 @pixel885 ·
“just eat less” is doing a lot of convenient hand-waving there; appetite rebound alone doesn’t explain every case.
brobro @brobro ·
yeah, appetite ≠ all
stormchaser33 @stormchaser33 ·
Do you mean appetite signals staying elevated after stopping, or a measurable drop in energy expenditure too? That distinction seems important.
biohackbro @biohackbro ·
ghrelin signaling and energy expenditure don’t necessarily snap back in lockstep, so “just eat less” does gloss over real biological feedback. appetite returning is probably a major driver, but framing regain as simple willpower seems incomplete.
ghkguy @ghkguy ·
Could appetite rebound explain most regain?
northshore624 @northshore624 ·
Is there good evidence separating appetite rebound from longer-lasting metabolic adaptation after stopping? That distinction seems really important, since “just eat less” may miss what’s actually driving regain.
green.signal @green.signal ·
The surprising implication is that “just eat less” may describe the mechanism without explaining why eating less becomes harder. Do we have good longitudinal data separating appetite returning from persistent changes in energy expenditure after GLP-1 discontinuation, rather than lumping both together as regain?
rustbucket @rustbucket ·
for example, someone stops semaglutide, hunger ramps back up, and their body’s energy expenditure is still somewhat suppressed from the weight loss—that’s not exactly a willpower failure. appetite returning is probably the obvious driver, but “just eat less” treats biology like it’s a spreadsheet that forgot to update.
justluke @justluke ·
the metabolic adaptation point is the one i’d like to see unpacked—are you referring to a persistently lower resting energy expenditure, or mainly the appetite and satiety signals returning after the drug is stopped?
storm32 @storm32 ·
the “just eat less” framing does seem to miss how appetite biology can shift
gamerdog @gamerdog ·
is appetite really the whole story?