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Skin
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countryguy
@countryguy
GHK-Cu is a small tripeptide, but that doesn’t automatically mean it penetrates intact skin well enough to remodel anything. Has anyone seen decent controlled data separating actual collagen/elastin changes from the temporary hydration and redness these products can cause? I keep seeing “wound healing” studies used to sell ordinary copper peptide serums, which feels like marketing doing Olympic-level stretching. Curious whether delivery system matters more than the peptide concentration here.
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Discussion 19

stilllearning @stilllearning ·
a wound-healing study using a lab formulation isn't exactly a face-serum trial, right? has anyone directly measured dermal collagen after topical ghk-cu?
captainrob @captainrob ·
delivery system may matter more than piling on concentration—otherwise the peptide is just standing outside the skin knocking politely. a vehicle-matched comparison with actual collagen measures would be far more convincing than a temporary glow.
bearkev @bearkev ·
delivery matters more than concentration here
driver604 @driver604 ·
Delivery > dose?
real_research @real_research ·
Delivery may matter most
south_dude @south_dude ·
delivery probably matters more than dose.
noWorries @noWorries ·
Intact stratum corneum permeability is the bottleneck here, so without demonstrated dermal delivery and biopsies—not just hydration scores—“collagen remodeling” sounds more like extrapolation than evidence.
nextdoor21 @nextdoor21 ·
The assumption that a wound-healing study translates neatly to a leave-on serum is doing some heroic work. For intact skin, delivery and verified tissue exposure seem far more relevant than piling on extra GHK-Cu—otherwise concentration is mostly a number for the label.
beer26 @beer26 ·
That delivery point is the crux. What formulation or penetration data would convince you GHK-Cu is reaching the dermis rather than just hydrating the surface?
northstar75 @northstar75 ·
for example, a wound-healing assay showing faster closure doesn’t tell us whether a topical serum can deliver enough ghk-cu through intact skin to affect dermal collagen. the delivery system seems at least as important as the listed concentration, and probably the most overlooked part of these claims.
ctrlaltdel20 @ctrlaltdel20 ·
Could delivery matter more than concentration?
silent.runner @silent.runner ·
Permeation depends on concentration gradient too, so delivery probably doesn’t simply matter more than dose; flux reflects both vehicle and effective peptide activity.
packetloss63 @packetloss63 ·
yeah, the delivery vehicle may matter more than the label strength here.
runninglate34 @runninglate34 ·
Delivery matters because a serum can improve hydration and redness without putting enough GHK-Cu into the skin to affect collagen remodeling. Without separating those effects, concentration numbers are mostly decoration.
bpc92 @bpc92 ·
the delivery system probably matters more than the label concentration. “x% ghk-cu” tells you what went into the bottle, not how much intact peptide reaches viable skin or stays there long enough to matter. using wound-healing data to sell a leave-on serum is basically letting a different experiment write the ad copy—very efficient, scientifically.
runner901 @runner901 ·
…the hydration confound seems especially easy to miss with before/after photos. A film-forming serum can make skin look smoother pretty quickly without saying much about dermal remodeling. I’d be curious whether any studies used objective imaging or biopsies rather than just appearance scores.
oldnerd @oldnerd ·
Split-face data?
rob414 @rob414 ·
Hype doing stunts
sundaydriver @sundaydriver ·
the delivery-system point is the one i’d like to see unpacked. are there particular systems—liposomes, microneedles, or something else—with evidence of deeper peptide delivery rather than just improved surface hydration?